Immunology – Biology 348
Fall 2018
This Drew University immunology course is offered each year in the Fall semester.
Course Periods: MWF 11:50AM-12:55PM
Location: Hall of Sciences 105
Instructor: Dr. Brianne Barker
Prerequisite:
The prerequisite for this course is BIOL 250 lecture and lab. The core concepts from these courses that I want you to be familiar with include:
- The Central Dogma of Molecular Biology, including DNA Replication, Transcription, Translation, DNA Repair, and Recombination
- Protein Structural Units and Amino Acids
- Mechanisms of Cell Communication and Signal Transduction
- Protein Transport and Sorting via the Biosynthetic/Secretory Pathway
- General molecular and cellular biology laboratory techniques including the use of a micropipette, aseptic technique, mammalian cell culture, and polymerase chain reaction
- Analysis of experimental data
- Principles of good scientific writing, including appropriate citation of sources
Student Learning Goals:
After successful completion of this course, you will be able to:
- Summarize the essential aspects of the molecular and cellular processes by which immune cells develop and function
- Explain the mechanisms by which immune cells collaborate to allow for broad responses to pathogens without damaging the host
- Apply your knowledge of molecular and cellular immunology to discuss immune disease in humans and therapies that utilize the immune system
- Describe methods used to immune responses and interpret data obtained by these methods.
- Critically evaluate immunologic data and formulate new hypotheses
Textbook:
The textbook for this course is Kuby Immunology (8thEdition) by Punt et al., W.H. Freeman Press.
Course Schedule – Fall 2018
This schedule is subject to change
Date Topic Reading Lecture Video
Aug 27 Hallmarks of Immunity Chapter 1 Video (low-quality audio)
Aug 29 Cells and Organs of the Immune System Ch. 2 p. 37-63 Video (low-quality audio)
Aug 31 Innate Immunity (Humoral) Ch. 4 p. 113-120, Ch. 5 Video
Sept 3 Innate Immunity (Cellular) Chapter 4 p. 120-160 Video
Sept 5 Innate Immunity (Cellular) Ch. 4 p. 120-160, Ch. 3 p. 89-91 Video
Sept 7 Antigens and Antibodies Chapter 3 p. 69-84 Video
Sept 10 Antibody Structure and Function Chapter 12 p. 433-448 Video
Sept 12 Antibody Techniques Ch. 20 p. 759-772, 781-788. Video
Sept 14 Generation of Antibody Diversity Chapter 6 p. 205-229 Video
Sept 17 Generation of Antibody Diversity Chapter 6 p. 205-229 Video
Sept 19 Primary Literature Paper Discussion Oettinger et al., Science
Sept 21 B Cell Development Ch. 2 p. 31-37, Ch. 6 p. 232-236 Video
Sept 24 B Cell Selection Ch. 6 p. 232-236, Ch. 9 p. 321-337 Video
Sept 26 T Cells and MHC Chapter 7 p. 249-275 Video
Sept 28 Exam 1
Oct 1 MHC Structure and Function Chapter 7 p. 249-275 Video
Oct 3 Antigen Processing and Presentation Chapter 7 p. 275-287 Video
Oct 5 Antigen Processing and Presentation Chapter 7 p. 275-287 Video
Oct 10 Primary Literature Paper Discussion Goulder et al., Nature 2001
Oct 12 TCR and T Cell Development Chapter 3 p. 84-89, Chapter 8 Video
Oct 15 T Cell Development Chapter 8
Oct 17 Immune Cell Trafficking Chapter 14 (Pages TBA). Video
Oct 19 Immune Cell Trafficking Chapter 14 (Pages TBA) Video
Oct 22 T Cell Activation Chapter 10 p. 353-367 Video
Oct 24 T Cell Effector Function Chapter 12 p. 448-459 Video
Oct 26 T Cell Subsets Chapter 3 p. 91-109, Chapter 6 p. 367-383 Video
Oct 29 Primary Literature Medzhitov et al., Nature 1997 and Poltorak et al., Science 1998
Oct 31 Peripheral B Cell Responses Chapter 11, Chapter 14 (pages TBA) Video
Nov 2 Exam 2
Nov 5 Peripheral B Cells/Kinetics Ch 10 p. 383-387, Ch 14 Video
Nov 7 Kinetics and Memory Ch 10 p. 383-387, Ch 14 Video
Nov 9 NK Cells Chapter 12 p. 459-468 Video
Nov 12 Peripheral Tolerance and Autoimmunity Chapter 16 p. 593-617 Video
Nov 14 Peripheral Tolerance and Autoimmunity Chapter 16 p. 593-617 Video
Nov 15 Primary Literature Paper Discussion in Lab Beura et al., Science 2016
Nov 16 Allergy and Hypersensitivity Chapter 15 Video
Nov 19 Allergy and Hypersensitivity Chapter 15 Video
Nov 26 Transplantation Chapter 16 p. 617-632 Video
Nov 28 Vaccines Chapter 17 p. 662-676 Video
Nov 30 HIV/AIDS Chapter 18 p. 699-722 Video
Dec 3 HIV/AIDS and Vaccines Chapter 18 p. 699-722 Video
Dec 5 Cancer Immunology Chapter 19 Video
Dec 6 Primary Literature Paper Discussion in Lab Jamieson et al., Cell Host and Microbe 2010
Dec 7 Primary Literature Paper Discussion Balazs et al., Nature 2011
