Course Periods: MWF 11:50AM-12:55PM
Location: Hall of Sciences 105
Instructor: Dr. Brianne Barker
Prerequisite:
The prerequisite for this course is BIOL 250 lecture and lab. The core concepts from these courses that I want you to be familiar with include:
- The Central Dogma of Molecular Biology, including DNA Replication, Transcription, Translation, DNA Repair, and Recombination
- Protein Structural Units and Amino Acids
- Mechanisms of Cell Communication and Signal Transduction
- Protein Transport and Sorting via the Biosynthetic/Secretory Pathway
- General molecular and cellular biology laboratory techniques including the use of a micropipette, aseptic technique, mammalian cell culture, and polymerase chain reaction
- Analysis of experimental data
- Principles of good scientific writing, including appropriate citation of sources
Student Learning Goals:
After successful completion of this course, you will be able to:
- Summarize the essential aspects of the molecular and cellular processes by which immune cells develop and function
- Explain the mechanisms by which immune cells collaborate to allow for broad responses to pathogens without damaging the host
- Apply your knowledge of molecular and cellular immunology to discuss immune disease in humans and therapies that utilize the immune system
- Describe methods used to immune responses and interpret data obtained by these methods.
- Critically evaluate immunologic data and formulate new hypotheses
Textbook:
The textbook for this course is Kuby Immunology (8thEdition) by Punt et al., W.H. Freeman Press.
Course Schedule – Fall 2019
This schedule is subject to change
Date Topic Reading Lecture Video
Aug 26 Hallmarks of Immunity Chapter 1 Video
Aug 28 Cells and Organs of the Immune System Ch. 2 p. 37-63 Video
Aug 30 Innate Immunity (Humoral) Ch. 4 p. 113-120, Ch. 5 Video
Sept 2 Innate Immunity (Cellular) Chapter 4 p. 120-160 Video
Sept 4 Innate Immunity (Cellular) Ch. 4 p. 120-160, Ch. 3 p. 89-91 Video
Sept 6 Antigens and Antibodies Chapter 3 p. 69-84 Video
Sept 9 Antibody Structure and Function Chapter 12 p. 433-448 Video
Sept 11 Generation of Antibody Diversity Chapter 6 p. 205-229 Video
Sept 13 Generation of Antibody Diversity Chapter 6 p. 205-229 Video
Sept 16 Antibody Techniques Ch. 20 p. 759-772, 781-788 Video
Sept 18 Primary Literature Paper Discussion Oettinger et al., Science 1990
Sept 20 B Cell Development Ch. 2 p. 31-37, Ch. 6 p. 232-236 Video
Sept 23 B Cell Selection Ch. 6 p. 232-236, Ch. 9 p. 321-337 Video
Sept 25 T Cells and MHC Chapter 7 p. 249-275 Video
Sept 27 Exam 1
Oct 2 MHC Structure and Function Chapter 7 p. 249-275 Video
Oct 4 Antigen Processing and Presentation Chapter 7 p. 275-287 Video
Oct 7 Antigen Processing and Presentation Chapter 7 p. 275-287 Video
Oct 9 TCR and T Cell Development Chapter 3 p. 84-89, Chapter 8 Video
Oct 11 T Cell Development Chapter 8 Video
Oct 14 Immune Cell Trafficking Chapter 14 (Pages TBA) Video
Oct 16 T Cell Activation Chapter 10 p. 353-367 Video
Oct 18 T Cell Effector Function Chapter 12 p. 448-459 Video
Oct 21 T Cell Subsets Chapter 3 p. 91-109, Chapter 6 p. 367-383 Video
Oct 23 Peripheral B Cell Responses Chapter 11, Chapter 14 (pages TBA) Video
Oct 25 Peripheral B Cell Responses Chapter 11, Chapter 14 (pages TBA) Video
Oct 28 Primary Literature Paper Discussion Roco et al., Immunity 2019
Oct 30 Primary Literature Paper Discussion Beura et al., Nature 2016
Nov 4 Exam 2
Nov 4 Kinetics and Memory Ch 10 p. 383-387, Ch 14. Video
Nov 6 NK Cells Chapter 12 p. 459-468 Video
Nov 8 Peripheral Tolerance and Autoimmunity Chapter 16 p. 593-617 Video
Nov 11 Peripheral Tolerance and Autoimmunity Chapter 16 p. 593-617 Video
Nov 13 Primary Literature Paper Discussion
Nov 15 Allergy and Hypersensitivity Chapter 15 Video
Nov 18 Allergy and Hypersensitivity Chapter 15 Video
Nov 20 Transplantation Chapter 16 p. 617-632 Video
Nov 22 Vaccines Chapter 17 p. 662-676 Video
Nov 25 Vaccines Chapter 17 p. 662-676 Video
Dec 2 Cancer Immunology Chapter 19 Video
Dec 4 HIV/AIDS Chapter 18 p. 699-722. Video
Dec 6 Primary Literature Paper Discussion
