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Immunology Course

Immunology – Biology 348

Fall 2018

This Drew University immunology course is offered each year in the Fall semester.

Course Periods: MWF 11:50AM-12:55PM

Location: Hall of Sciences 105

Instructor: Dr. Brianne Barker

Prerequisite:

The prerequisite for this course is BIOL 250 lecture and lab.  The core concepts from these courses that I want you to be familiar with include:

  • The Central Dogma of Molecular Biology, including DNA Replication, Transcription, Translation, DNA Repair, and Recombination
  • Protein Structural Units and Amino Acids
  • Mechanisms of Cell Communication and Signal Transduction
  • Protein Transport and Sorting via the Biosynthetic/Secretory Pathway
  • General molecular and cellular biology laboratory techniques including the use of a micropipette, aseptic technique, mammalian cell culture, and polymerase chain reaction
  • Analysis of experimental data
  • Principles of good scientific writing, including appropriate citation of sources

Student Learning Goals:

After successful completion of this course, you will be able to:

  • Summarize the essential aspects of the molecular and cellular processes by which immune cells develop and function
  • Explain the mechanisms by which immune cells collaborate to allow for broad responses to pathogens without damaging the host
  • Apply your knowledge of molecular and cellular immunology to discuss immune disease in humans and therapies that utilize the immune system
  • Describe methods used to immune responses and interpret data obtained by these methods.
  • Critically evaluate immunologic data and formulate new hypotheses

Textbook: 

The textbook for this course is Kuby Immunology (8thEdition) by Punt et al., W.H. Freeman Press.

 

Course Schedule – Fall 2018

This schedule is subject to change

Date                         Topic                                                                         Reading                                   Lecture Video                                                          

Aug 27                    Hallmarks of Immunity                                      Chapter 1              Video (low-quality audio)

Aug 29                    Cells and Organs of the Immune System      Ch. 2 p. 37-63       Video (low-quality audio)

Aug 31                     Innate Immunity (Humoral)                              Ch. 4 p. 113-120, Ch. 5                      Video

Sept 3                      Innate Immunity (Cellular)                               Chapter 4 p. 120-160                        Video

Sept 5                      Innate Immunity (Cellular)                               Ch. 4 p. 120-160, Ch. 3 p. 89-91      Video

Sept 7                      Antigens and Antibodies                                 Chapter 3 p. 69-84                           Video

Sept 10                    Antibody Structure and Function                   Chapter 12 p. 433-448                     Video

Sept 12                    Antibody Techniques                                        Ch. 20 p. 759-772, 781-788.            Video

Sept 14                    Generation of Antibody Diversity                    Chapter 6 p. 205-229                      Video

Sept 17                    Generation of Antibody Diversity                    Chapter 6 p. 205-229                      Video

Sept 19                    Primary Literature Paper Discussion          Oettinger et al., Science

Sept 21                    B Cell Development                                           Ch. 2 p. 31-37, Ch. 6 p. 232-236    Video

Sept 24                    B Cell Selection                                                  Ch. 6 p. 232-236, Ch. 9 p. 321-337 Video

Sept 26                   T Cells and MHC                                                 Chapter 7 p. 249-275                      Video

Sept 28                   Exam 1

Oct 1                       MHC Structure and Function                           Chapter 7 p. 249-275                       Video

Oct 3                      Antigen Processing and Presentation              Chapter 7 p. 275-287                      Video

Oct 5                      Antigen Processing and Presentation              Chapter 7 p. 275-287                      Video

Oct 10                    Primary Literature Paper Discussion            Goulder et al., Nature 2001

Oct 12                     TCR and T Cell Development                           Chapter 3 p. 84-89, Chapter 8      Video

Oct 15                     T Cell Development                                            Chapter 8

Oct 17                    Immune Cell Trafficking                                    Chapter 14 (Pages TBA).                 Video

Oct 19                    Immune Cell Trafficking                                    Chapter 14 (Pages TBA)                  Video

Oct 22                    T Cell Activation                                               Chapter 10 p. 353-367                        Video

Oct 24                    T Cell Effector Function                                  Chapter 12 p. 448-459                       Video

Oct 26                    T Cell Subsets                                      Chapter 3 p. 91-109, Chapter 6 p. 367-383 Video

Oct 29                    Primary Literature   Medzhitov et al., Nature 1997  and Poltorak et al., Science 1998

Oct 31                     Peripheral B Cell Responses                           Chapter 11, Chapter 14 (pages TBA) Video

Nov 2                      Exam 2

Nov 5                      Peripheral B Cells/Kinetics                           Ch 10 p. 383-387, Ch 14                     Video

Nov 7                      Kinetics and Memory                                      Ch 10 p. 383-387, Ch 14                     Video

Nov 9                      NK Cells                                                              Chapter 12 p. 459-468

Nov 12                    Peripheral Tolerance and Autoimmunity    Chapter 16 p. 593-617

Nov 14                    Peripheral Tolerance and Autoimmunity     Chapter 16 p. 593-617

Nov 16                    Allergy and Hypersensitivity                         Chapter 15

Nov 19                    Allergy and Hypersensitivity                         Chapter 15

Nov 26                    Transplantation                                               Chapter 16 p. 617-632

Nov 28                    Vaccines                                                            Chapter 17 p. 662-676

Nov 30                    HIV/AIDS                                                        Chapter 18 p. 699-722

Dec 3                      Cancer Immunology                                       Chapter 19

Dec 5                      Primary Literature Paper Discussion

Dec 7                      Primary Literature Paper Discussion

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