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Immunology Course

Immunology – Biology 348

Fall 2019

This Drew University immunology course is offered each year in the Fall semester.

For the Fall 2018 version of the course, click here

Course Periods: MWF 11:50AM-12:55PM

Location: Hall of Sciences 105

Instructor: Dr. Brianne Barker

Prerequisite:

The prerequisite for this course is BIOL 250 lecture and lab.  The core concepts from these courses that I want you to be familiar with include:

  • The Central Dogma of Molecular Biology, including DNA Replication, Transcription, Translation, DNA Repair, and Recombination
  • Protein Structural Units and Amino Acids
  • Mechanisms of Cell Communication and Signal Transduction
  • Protein Transport and Sorting via the Biosynthetic/Secretory Pathway
  • General molecular and cellular biology laboratory techniques including the use of a micropipette, aseptic technique, mammalian cell culture, and polymerase chain reaction
  • Analysis of experimental data
  • Principles of good scientific writing, including appropriate citation of sources

Student Learning Goals:

After successful completion of this course, you will be able to:

  • Summarize the essential aspects of the molecular and cellular processes by which immune cells develop and function
  • Explain the mechanisms by which immune cells collaborate to allow for broad responses to pathogens without damaging the host
  • Apply your knowledge of molecular and cellular immunology to discuss immune disease in humans and therapies that utilize the immune system
  • Describe methods used to immune responses and interpret data obtained by these methods.
  • Critically evaluate immunologic data and formulate new hypotheses

Textbook: 

The textbook for this course is Kuby Immunology (8thEdition) by Punt et al., W.H. Freeman Press.

Course Schedule – Fall 2019

This schedule is subject to change

Date                         Topic                                                                         Reading                                   Lecture Video                                                          

Aug 26                    Hallmarks of Immunity                                      Chapter 1                          Video

Aug 28                    Cells and Organs of the Immune System      Ch. 2 p. 37-63                   Video

Aug 30                     Innate Immunity (Humoral)                              Ch. 4 p. 113-120, Ch. 5      Video

Sept 2                      Innate Immunity (Cellular)                               Chapter 4 p. 120-160                Video

Sept 4                      Innate Immunity (Cellular)                               Ch. 4 p. 120-160, Ch. 3 p. 89-91   Video

Sept 6                      Antigens and Antibodies                                 Chapter 3 p. 69-84                   Video

Sept 9                    Antibody Structure and Function                   Chapter 12 p. 433-448               Video

Sept 11                    Generation of Antibody Diversity                    Chapter 6 p. 205-229               Video

Sept 13                    Generation of Antibody Diversity                    Chapter 6 p. 205-229                Video

Sept 16                     Antibody Techniques                                        Ch. 20 p. 759-772, 781-788      Video

Sept 18                    Primary Literature Paper Discussion        Oettinger et al., Science 1990

Sept 20                    B Cell Development                                           Ch. 2 p. 31-37, Ch. 6 p. 232-236  Video

Sept 23                    B Cell Selection                                                  Ch. 6 p. 232-236, Ch. 9 p. 321-337 Video

Sept 25                   T Cells and MHC                                                 Chapter 7 p. 249-275                            Video

Sept 27                   Exam 1

Oct 2                       MHC Structure and Function                           Chapter 7 p. 249-275                            Video

Oct 4                      Antigen Processing and Presentation              Chapter 7 p. 275-287                        Video

Oct 7                     Antigen Processing and Presentation              Chapter 7 p. 275-287                            Video

Oct 9                     TCR and T Cell Development                           Chapter 3 p. 84-89, Chapter 8           Video

Oct 11                     T Cell Development                                            Chapter 8                                        Video

Oct 14                   Immune Cell Trafficking                                    Chapter 14 (Pages TBA)                    Video

Oct 16                     T Cell Activation                                               Chapter 10 p. 353-367                           Video

Oct 18                     T Cell Effector Function                                  Chapter 12 p. 448-459                          Video

Oct 21                     T Cell Subsets                                      Chapter 3 p. 91-109, Chapter 6 p. 367-383     Video

Oct 23                     Peripheral B Cell Responses                           Chapter 11, Chapter 14 (pages TBA)   Video

Oct 25                     Peripheral B Cell Responses                           Chapter 11, Chapter 14 (pages TBA)     Video

Oct 28                     Primary Literature Paper Discussion               Roco et al., Immunity 2019

Oct 30                    Primary Literature Paper Discussion               Beura et al., Nature 2016

Nov 4                      Exam 2

Nov 4                      Kinetics and Memory                                      Ch 10 p. 383-387, Ch 14

Nov 6                      NK Cells                                                              Chapter 12 p. 459-468

Nov 8                      Peripheral Tolerance and Autoimmunity    Chapter 16 p. 593-617

Nov 11                    Peripheral Tolerance and Autoimmunity    Chapter 16 p. 593-617

Nov 13                     Primary Literature Paper Discussion

Nov 15                   Allergy and Hypersensitivity                         Chapter 15

Nov 18                    Allergy and Hypersensitivity                         Chapter 15

Nov 20                    Transplantation      Chapter 16 p. 617-632

Nov 22                    Vaccines                                               Chapter 17 p. 662-676

Nov 25                   HIV/AIDS                                                              Chapter 18 p. 699-722

Dec 2                    Cancer Immunology                                                      Chapter 19

Dec 4                      Primary Literature Paper Discussion

Dec 6                     Primary Literature Paper Discussion

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