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Immunology Course

Immunology – Biology 348

Fall 2019

This Drew University immunology course is offered each year in the Fall semester.

For the Fall 2018 version of the course, click here

Course Periods: MWF 11:50AM-12:55PM

Location: Hall of Sciences 105

Instructor: Dr. Brianne Barker

Prerequisite:

The prerequisite for this course is BIOL 250 lecture and lab.  The core concepts from these courses that I want you to be familiar with include:

  • The Central Dogma of Molecular Biology, including DNA Replication, Transcription, Translation, DNA Repair, and Recombination
  • Protein Structural Units and Amino Acids
  • Mechanisms of Cell Communication and Signal Transduction
  • Protein Transport and Sorting via the Biosynthetic/Secretory Pathway
  • General molecular and cellular biology laboratory techniques including the use of a micropipette, aseptic technique, mammalian cell culture, and polymerase chain reaction
  • Analysis of experimental data
  • Principles of good scientific writing, including appropriate citation of sources

Student Learning Goals:

After successful completion of this course, you will be able to:

  • Summarize the essential aspects of the molecular and cellular processes by which immune cells develop and function
  • Explain the mechanisms by which immune cells collaborate to allow for broad responses to pathogens without damaging the host
  • Apply your knowledge of molecular and cellular immunology to discuss immune disease in humans and therapies that utilize the immune system
  • Describe methods used to immune responses and interpret data obtained by these methods.
  • Critically evaluate immunologic data and formulate new hypotheses

Textbook: 

The textbook for this course is Kuby Immunology (8thEdition) by Punt et al., W.H. Freeman Press.

Course Schedule – Fall 2019

This schedule is subject to change

Date                         Topic                                                                         Reading                                   Lecture Video                                                          

Aug 26                    Hallmarks of Immunity                                      Chapter 1                          Video

Aug 28                    Cells and Organs of the Immune System      Ch. 2 p. 37-63                   Video

Aug 30                     Innate Immunity (Humoral)                              Ch. 4 p. 113-120, Ch. 5      Video

Sept 2                      Innate Immunity (Cellular)                               Chapter 4 p. 120-160                Video

Sept 4                      Innate Immunity (Cellular)                               Ch. 4 p. 120-160, Ch. 3 p. 89-91   Video

Sept 6                      Antigens and Antibodies                                 Chapter 3 p. 69-84                   Video

Sept 9                    Antibody Structure and Function                   Chapter 12 p. 433-448               Video

Sept 11                    Generation of Antibody Diversity                    Chapter 6 p. 205-229               Video

Sept 13                    Generation of Antibody Diversity                    Chapter 6 p. 205-229                Video

Sept 16                     Antibody Techniques                                        Ch. 20 p. 759-772, 781-788      Video

Sept 18                    Primary Literature Paper Discussion        Oettinger et al., Science 1990

Sept 20                    B Cell Development                                           Ch. 2 p. 31-37, Ch. 6 p. 232-236  Video

Sept 23                    B Cell Selection                                                  Ch. 6 p. 232-236, Ch. 9 p. 321-337

Sept 25                   T Cells and MHC                                                 Chapter 7 p. 249-275

Sept 27                   Exam 1

Oct 2                       MHC Structure and Function                           Chapter 7 p. 249-275

Oct 4                      Antigen Processing and Presentation              Chapter 7 p. 275-287

Oct 7                     Antigen Processing and Presentation              Chapter 7 p. 275-287

Oct 9                    Primary Literature Paper Discussion          

Oct 11                     TCR and T Cell Development                           Chapter 3 p. 84-89, Chapter 8

Oct 14                     T Cell Development                                            Chapter 8

Oct 16                     Primary Literature Paper Discussion

Oct 18                    Immune Cell Trafficking                                    Chapter 14 (Pages TBA).

Oct 21                    T Cell Activation                                               Chapter 10 p. 353-367

Oct 23                    T Cell Effector Function                                  Chapter 12 p. 448-459

Oct 25                    T Cell Subsets                                      Chapter 3 p. 91-109, Chapter 6 p. 367-383

Oct 28                 Peripheral B Cell Responses                           Chapter 11, Chapter 14 (pages TBA)

Oct 30                     Peripheral B Cell Responses                           Chapter 11, Chapter 14 (pages TBA)

Nov 1                      Exam 2

Nov 4                      Kinetics and Memory                                      Ch 10 p. 383-387, Ch 14

Nov 6                      NK Cells                                                              Chapter 12 p. 459-468

Nov 8                      Peripheral Tolerance and Autoimmunity    Chapter 16 p. 593-617

Nov 11                    Peripheral Tolerance and Autoimmunity    Chapter 16 p. 593-617

Nov 13                     Primary Literature Paper Discussion

Nov 15                   Allergy and Hypersensitivity                         Chapter 15

Nov 18                    Allergy and Hypersensitivity                         Chapter 15

Nov 20                    Transplantation      Chapter 16 p. 617-632

Nov 22                    Vaccines                                               Chapter 17 p. 662-676

Nov 25                   HIV/AIDS                                                              Chapter 18 p. 699-722

Dec 2                    Cancer Immunology                                                      Chapter 19

Dec 4                      Primary Literature Paper Discussion

Dec 6                     Primary Literature Paper Discussion

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